Before using investigational drugs in people, researchers can use some types of stem cells to test the drugs for safety and quality. Test new drugs for safety and effectiveness. Researchers continue to advance the knowledge on stem cells and their applications in transplant and regenerative medicine. Stem cells may have the potential to be grown to become new tissue for use in transplant and regenerative medicine. The voyage of discovery consists not just in seeking new lands but in seeing with new eyes.People who might benefit from stem cell therapies include those with spinal cord injuries, type 1 diabetes, Parkinson's disease, amyotrophic lateral sclerosis, Alzheimer's disease, heart disease, stroke, burns, cancer and osteoarthritis.
The Department of Stem Cell Biology & Regenerative Medicine’s mission is to battle tissue degeneration, aging and cancer by making scientific progress in: The department is also heavily involved in biomedical education through the training of graduate students and postdoctoral fellows and high school and undergraduate students through CIRM-funded STEM programs, including the CIRM/COH Research Training Program in Stem Cell Biology and Regenerative Medicine. Research in the Department is funded by the National Institutes of Health (NIH) and California Institute for Regenerative Medicine (CIRM). These efforts have naturally evolved and expanded and are at the core of Department of Stem Cell Biology & Regenerative Medicine’s mission today. Studies on neurobiology and brain tumors conducted in the original Neurosciences department set a remarkable paradigm for interdisciplinary research and generated discoveries that advanced our understanding of other cellular systems and treatments of many other cancers, including ovarian, breast, and prostate cancers, as well as hematological malignancies.
Historically, the Department of Stem Cell Biology & Regenerative Medicine (previously called the Department of Developmental & Stem Cell Biology) has grown from its original founding as the Department of Neurosciences, one of the first neurobiology departments in North America and established by Dr. The Department supports several clinical trials and has strong collaborations with the City of Hope Clinical Oncology and Immunotherapy programs to develop new approaches using stem cells as drug discovery platforms as well as delivery systems for cancer therapeutics. Research in the Department is highly multidisciplinary and couples stem cell and developmental biology with computational and systems biology to resolve the complexity of biological processes, identify the mechanisms underlying diseases, and create new knowledge to lay the foundation for new therapies. Department researchers work very closely with mathematical biologists and oncologists in the Department of Computational and Quantitative Medicine and at TGEN, and with physician-scientists in the City of Hope Medical Center. These research programs study stem cells and induced pluripotent cells using advanced microscopy, as well as gene manipulation techniques to reprogram the cells with the goal of using them to improve and repair tissue functions. The Department has active programs in neurobiology, neurodegenerative diseases, hematopoiesis and vascular biology, cardio-oncology, immuno-oncology, cancer biology, and aging. Research teams in the department explore fundamental questions in developmental and stem cell biology to develop new approaches that can be applied to regenerative medicine and novel cancer therapeutics. Research in the Department of Stem Cell Biology & Regenerative Medicine is firmly rooted in discovery biology.
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